PDBe 5e4e

X-ray diffraction
3Å resolution

Engineered Interleukin-13 bound to receptor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.46 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P35225 (Residues: 34-146; Coverage: 100%)
Gene names: IL13, NC30
Structure domains: Growth Hormone; Chain: A;
Soluble interleukin-4 receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 203 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P24394 (Residues: 26-228; Coverage: 25%)
Gene names: 582J2.1, IL4R, IL4RA
Sequence domains: Interleukin-4 receptor alpha chain, N-terminal
Structure domains: Immunoglobulins
Interleukin-13 receptor subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 318 amino acids
Theoretical weight: 36.57 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P78552 (Residues: 23-340; Coverage: 78%)
Gene names: IL13R, IL13RA, IL13RA1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Unit cell:
a: 62.59Å b: 69.37Å c: 186.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.288
Expression system: Trichoplusia ni