› 5dxx

X-ray diffraction
1.45Å resolution

Crystal structure of Dbr2

Released:
DOI: 10.2210/pdb5dxx/pdb
PDB entry 5dxx coloured by chain, front view.
PDB entry 5dxx coloured by chain, side view.
PDB entry 5dxx coloured by chain, top view.
Source organism: Artemisia annua
Entry authors: Li L, Chen TT, Xu YC

Function and Biology Details

Reaction catalysed: 
(11R)-dihydroartemisinic aldehyde + NADP(+) = artemisinic aldehyde + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Artemisinic aldehyde Delta(11(13)) reductase Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 42.5 KDa
Source organism: Artemisia annua
Expression system: Escherichia coli
UniProt:
  • Canonical: C5H429 (Residues: 1-388; Coverage: 100%)
Gene names: AAR, DBR2
Sequence domains: NADH:flavin oxidoreductase / NADH oxidase family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:
Ligand FMN 1 x FMN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 52.58Å b: 80.97Å c: 86.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.131 0.13 0.163
Expression system: Escherichia coli

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