› 5dvb

X-ray diffraction
2.2Å resolution

Crystal Structure of S. cerevisiae TSA2

Released:
DOI: 10.2210/pdb5dvb/pdb
PDB entry 5dvb coloured by chain, front view.
PDB entry 5dvb coloured by chain, side view.
PDB entry 5dvb coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of TSA2 reveals novel features of the active-site loop of peroxiredoxins.
Nielsen MH, Kidmose RT, Jenner LB
Acta Crystallogr D Struct Biol 72 158-67 (2016)
PMID: 26894543

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin TSA2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 217 amino acids
Theoretical weight: 24.2 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q04120 (Residues: 1-196; Coverage: 100%)
Gene names: D9461.38, TSA2, YDR453C
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P21212
Unit cell:
a: 171.53Å b: 216.13Å c: 64.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.233
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Protein Promiscuity in H2O2 Signaling.
Young et al. (2019)
3 other articles

2 mentions without citation

Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms.
Tairum et al. (2016)
1 more