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Crystal Structure of the Homocysteine Methyltransferase MmuM from Escherichia coli, Metallated form

Source organism: Escherichia coli K-12
Biochemical function: S-methylmethionine-homocysteine S-methyltransferase activity
Biological process: S-methylmethionine cycle
Cellular component: not assigned

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EC 2.1.1.10: Homocysteine S-methyltransferase

Reaction catalysed:
S-methyl-L-methionine + L-homocysteine = 2 L-methionine
Systematic name:
S-adenosyl-L-methionine:L-homocysteine S-methyltransferase
Alternative Name(s):
  • Adenosylmethionine transmethylase
  • Adenosylmethionine:homocysteine methyltransferase
  • Homocysteine methylase
  • Homocysteine methyltransferase
  • Homocysteine transmethylase
  • L-homocysteine S-methyltransferase
  • Methylmethionine:homocysteine methyltransferase
  • S-adenosyl-L-methionine:L-homocysteine methyltransferase
  • S-adenosylmethionine homocysteine transmethylase
  • S-adenosylmethionine-homocysteine transmethylase
  • S-adenosylmethionine:homocysteine methyltransferase
  • S-methylmethionine homocysteine transmethylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02574
Domain description: Homocysteine S-methyltransferase
Occurring in:
  1. Homocysteine S-methyltransferase
The deposited structure of PDB entry 5dmm contains 1 copy of Pfam domain PF02574 (Homocysteine S-methyltransferase) in Homocysteine S-methyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR017226
Domain description: Betaine-homocysteine S-methyltransferase, BHMT
Occurring in:
  1. Homocysteine S-methyltransferase
IPR003726
Domain description: Homocysteine-binding domain
Occurring in:
  1. Homocysteine S-methyltransferase
IPR036589
Domain description: Homocysteine-binding domain superfamily
Occurring in:
  1. Homocysteine S-methyltransferase

Structure domain

CATH CATH domain
3.20.20.330
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Homocysteine-binding-like domain
Occurring in:
  1. Homocysteine S-methyltransferase
The deposited structure of PDB entry 5dmm contains 1 copy of CATH domain 3.20.20.330 (TIM Barrel) in Homocysteine S-methyltransferase. Showing 1 copy in chain A.

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