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Crystal Structure of Pembrolizumab, a full length IgG4 antibody

X-ray diffraction
2.28Å resolution
PDB entry 5dk3 coloured by chain, front view.
PDB entry 5dk3 coloured by chain, side view.
PDB entry 5dk3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero tetramer
Accessible surface area: 58989.73 Å2
Buried surface area: 19956.12 Å2
Dissociation area: 1,947.72 Å2
Dissociation energy (ΔGdiss): 22.78 kcal/mol
Dissociation entropy (TΔSdiss): 14.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-213712

Macromolecules

Light Chain
Chains: A, F
Length: 218 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Mammalia
InterPro:
CATH: Immunoglobulins
Light Chain in PDB entry 5dk3, assembly 1, front view.
Light Chain in PDB entry 5dk3, assembly 1, side view.
Light Chain in PDB entry 5dk3, assembly 1, top view.
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Heavy Chain
Chains: B, G
Length: 444 amino acids
Theoretical weight: 49.17 KDa
Source organism: Homo sapiens
Expression system: Mammalia
InterPro:
CATH: Immunoglobulins
Heavy Chain in PDB entry 5dk3, assembly 1, front view.
Heavy Chain in PDB entry 5dk3, assembly 1, side view.
Heavy Chain in PDB entry 5dk3, assembly 1, top view.
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