5dk3

X-ray diffraction
2.28Å resolution

Crystal Structure of Pembrolizumab, a full length IgG4 antibody

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Light Chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 218 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Mammalia
Structure domains: Immunoglobulins
Heavy Chain Chains: B, G
Molecule details ›
Chains: B, G
Length: 444 amino acids
Theoretical weight: 49.17 KDa
Source organism: Homo sapiens
Expression system: Mammalia

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 63.83Å b: 110.83Å c: 264.96Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.224
Expression system: Mammalia