X-ray diffraction
2.78Å resolution

Structural mechanism of Nek7 activation by Nek9-induced dimerisation


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase Nek7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 310 amino acids
Theoretical weight: 35.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8TDX7 (Residues: 1-302; Coverage: 100%)
Gene name: NEK7
Sequence domains: Protein kinase domain
Structure domains:
Serine/threonine-protein kinase Nek9 Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.23 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q8K1R7 (Residues: 817-835; Coverage: 2%)
Gene names: Nek9, Nercc

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3121
Unit cell:
a: 88.12Å b: 88.12Å c: 155.61Å
α: 90° β: 90° γ: 120°
R R work R free
0.208 0.206 0.254
Expression systems:
  • Escherichia coli
  • Not provided