› 5ddl

X-ray diffraction
1.98Å resolution

Crystal Structure of WT Human Glutathione Transferase Pi soaked with a metalloid then back-soaked with glutathione

Released:
DOI: 10.2210/pdb5ddl/pdb
PDB 5ddl coloured by chain and viewed from the front.
PDB 5ddl coloured by chain and viewed from the side.
PDB 5ddl coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Parker LJ, Parker MW, Morton CJ

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09211 (Residues: 1-210; Coverage: 100%)
Gene names: FAEES3, GST3, GSTP1
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand 5AU 2 x 5AU

Cofactor: Ligand GSH 2 x GSH
3 bound ligands:
Ligand MES 2 x MES
Ligand SO4 1 x SO4
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 77.665Å b: 89.795Å c: 68.854Å
α: 90° β: 98.08° γ: 90°
R-values:
R R work R free
0.14 0.138 0.178
Expression system: Escherichia coli

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