5das

X-ray diffraction
2.2Å resolution

Structure of Mycobacterium tuberculosis NadD in complex with NADP, P21212, form 2

Released:
Entry author: Korotkov KV

Function and Biology Details

Reaction catalysed:
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+)
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable nicotinate-nucleotide adenylyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 201 amino acids
Theoretical weight: 22.35 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WJJ5 (Residues: 1-192; Coverage: 91%)
Gene names: MTCY428.26, Rv2421c, nadD
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 117.82Å b: 156.13Å c: 48.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.239
Expression system: Escherichia coli