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Crystal structure of NalD, the secondary repressor of MexAB-OprM multidrug efflux pump in Pseudomonas aeruginosa

X-ray diffraction
2.65Å resolution
PDB entry 5daj coloured by chain, front view.
PDB entry 5daj coloured by chain, side view.
PDB entry 5daj coloured by chain, top view.
Source organism: Pseudomonas aeruginosa PAO1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 17298.43 Å2
Buried surface area: 3886.26 Å2
Dissociation area: 1,943.13 Å2
Dissociation energy (ΔGdiss): 17.71 kcal/mol
Dissociation entropy (TΔSdiss): 13.18 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191133
Assembly 2
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 17886.55 Å2
Buried surface area: 3906.07 Å2
Dissociation area: 1,953.03 Å2
Dissociation energy (ΔGdiss): 13.21 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191133
Assembly 3 (preferred)
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 17158.6 Å2
Buried surface area: 3820.5 Å2
Dissociation area: 1,910.25 Å2
Dissociation energy (ΔGdiss): 14.32 kcal/mol
Dissociation entropy (TΔSdiss): 13.13 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191133
Assembly 4
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 17396.82 Å2
Buried surface area: 3956.17 Å2
Dissociation area: 1,978.08 Å2
Dissociation energy (ΔGdiss): 17.54 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191133

Macromolecules

HTH tetR-type domain-containing protein
Chains: A, B, C, D, E, F, G, H
Length: 212 amino acids
Theoretical weight: 24.84 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HY46 (Residues: 1-212; Coverage: 100%)
Gene names: PA3574, nalD
Pfam:
InterPro:
CATH: Tetracycline Repressor, domain 2
HTH tetR-type domain-containing protein in PDB entry 5daj, assembly 3, front view.
HTH tetR-type domain-containing protein in PDB entry 5daj, assembly 3, side view.
HTH tetR-type domain-containing protein in PDB entry 5daj, assembly 3, top view.
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