X-ray diffraction
2.75Å resolution

A Dimerization-Dependent Mechanism Drives PRRSV NSP11 Functions As a Beta Interferon Antagonist and Endoribonuclease

Entry authors: Shi Y, Peng G

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Non-structural protein 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.72 KDa
Source organism: Porcine reproductive and respiratory syndrome virus
Expression system: Escherichia coli
  • Canonical: E3V2B6 (Residues: 1085-1307; Coverage: 15%)
Sequence domains: Coronavirus replicase NSP15, uridylate-specific endoribonuclease

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 77.317Å b: 77.317Å c: 204.693Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.211 0.282
Expression system: Escherichia coli