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Influenza C Virus RNA-dependent RNA Polymerase - Space group P212121

Source organism: Influenza C virus (C/Johannesburg/1/66)
Biochemical function: RNA binding
Biological process: viral RNA genome replication
Cellular component: host cell nucleus

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EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF20952
Domain description: Influenza RNA polymerase PB2 C-terminal domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20952 (Influenza RNA polymerase PB2 C-terminal domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF20951
Domain description: Influenza RNA polymerase PB2 6th domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20951 (Influenza RNA polymerase PB2 6th domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF00604
Domain description: Influenza RNA polymerase PB2 CAP binding domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF00604 (Influenza RNA polymerase PB2 CAP binding domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF20950
Domain description: Influenza RNA polymerase PB2 helical domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20950 (Influenza RNA polymerase PB2 helical domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF20949
Domain description: Influenza RNA polymerase PB2 middle domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20949 (Influenza RNA polymerase PB2 middle domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF20948
Domain description: Influenza RNA polymerase PB2 second domain
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20948 (Influenza RNA polymerase PB2 second domain) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF20947
Domain description: Influenza RNA polymerase PB2 N-terminal region
Occurring in:
  1. Polymerase basic protein 2
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF20947 (Influenza RNA polymerase PB2 N-terminal region) in Polymerase basic protein 2. Showing 1 copy in chain F.

PF00602
Domain description: Influenza RNA-dependent RNA polymerase subunit PB1
Occurring in:
  1. RNA-directed RNA polymerase catalytic subunit
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF00602 (Influenza RNA-dependent RNA polymerase subunit PB1) in RNA-directed RNA polymerase catalytic subunit. Showing 1 copy in chain B.

PF00603
Domain description: Influenza RNA-dependent RNA polymerase subunit PA
Occurring in:
  1. Polymerase acidic protein
The deposited structure of PDB entry 5d9a contains 4 copies of Pfam domain PF00603 (Influenza RNA-dependent RNA polymerase subunit PA) in Polymerase acidic protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001407
Domain description: Influenza RNA-dependent RNA polymerase subunit PB1
Occurring in:
  1. RNA-directed RNA polymerase catalytic subunit
IPR001591
Domain description: Influenza RNA-dependent RNA polymerase subunit PB2
Occurring in:
  1. Polymerase basic protein 2
IPR007099
Domain description: RNA-directed RNA polymerase, negative-strand RNA virus
Occurring in:
  1. RNA-directed RNA polymerase catalytic subunit
IPR001009
Domain description: Influenza RNA-dependent RNA polymerase subunit PA
Occurring in:
  1. Polymerase acidic protein
IPR038372
Domain description: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain
Occurring in:
  1. Polymerase acidic protein
IPR037534
Domain description: Polymerase acidic protein
Occurring in:
  1. Polymerase acidic protein

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