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Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795

X-ray diffraction
2.75Å resolution
PDB entry 5d3e coloured by chain, front view.
PDB entry 5d3e coloured by chain, side view.
PDB entry 5d3e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cystic fibrosis transmembrane conductance regulator and 14-3-3 protein gamma
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Multimeric state: hetero trimer
Accessible surface area: 24034.39 Å2
Buried surface area: 3906.52 Å2
Dissociation area: 911.23 Å2
Dissociation energy (ΔGdiss): 11.75 kcal/mol
Dissociation entropy (TΔSdiss): 8.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146641
Assembly 2
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Assembly Name: Cystic fibrosis transmembrane conductance regulator and 14-3-3 protein gamma
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Multimeric state: hetero trimer
Accessible surface area: 23706.37 Å2
Buried surface area: 3656.82 Å2
Dissociation area: 808.39 Å2
Dissociation energy (ΔGdiss): 9.15 kcal/mol
Dissociation entropy (TΔSdiss): 8.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146641
Assembly 3
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Assembly Name: Cystic fibrosis transmembrane conductance regulator and 14-3-3 protein gamma
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Multimeric state: hetero trimer
Accessible surface area: 23709.86 Å2
Buried surface area: 2814.16 Å2
Dissociation area: 459.54 Å2
Dissociation energy (ΔGdiss): 7.61 kcal/mol
Dissociation entropy (TΔSdiss): 7.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146641

Macromolecules

14-3-3 protein gamma
Chains: A, B, E, F, I, J
Length: 241 amino acids
Theoretical weight: 27.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61981 (Residues: 1-238; Coverage: 96%)
Gene name: YWHAG
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein gamma in PDB entry 5d3e, assembly 1, front view.
14-3-3 protein gamma in PDB entry 5d3e, assembly 1, side view.
14-3-3 protein gamma in PDB entry 5d3e, assembly 1, top view.
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Cystic fibrosis transmembrane conductance regulator
Chains: C, G, K
Length: 40 amino acids
Theoretical weight: 4.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13569 (Residues: 762-801; Coverage: 3%)
Gene names: ABCC7, CFTR
InterPro: CFTR regulator domain
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d3e, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d3e, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d3e, assembly 1, top view.
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