GO terms
Biochemical function:
Biological process:
- negative regulation of forebrain neuron differentiation
- positive regulation of cellular senescence
- amyloid fibril formation
- positive regulation of transferrin receptor binding
- positive regulation of ferrous iron binding
- positive regulation of receptor binding
- negative regulation of receptor binding
- cellular response to nicotine
- cellular response to iron(III) ion
- cellular response to iron ion
- multicellular organismal-level iron ion homeostasis
- protein homotetramerization
- positive regulation of T cell activation
- positive regulation of immune response
- negative regulation of neurogenesis
- negative regulation of epithelial cell proliferation
- positive regulation of receptor-mediated endocytosis
- regulation of erythrocyte differentiation
- protein refolding
- regulation of iron ion transport
- T cell differentiation in thymus
- positive regulation of protein binding
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- negative regulation of neuron projection development
- learning or memory
- sensory perception of smell
- immune response
- intracellular iron ion homeostasis
- iron ion transport
- positive regulation of T cell cytokine production
- peptide antigen assembly with MHC class II protein complex
- peptide antigen assembly with MHC class I protein complex
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
- antigen processing and presentation of peptide antigen via MHC class I
- response to molecule of bacterial origin
- positive regulation of T cell mediated cytotoxicity
- T cell mediated cytotoxicity
Cellular component:
- HFE-transferrin receptor complex
- tertiary granule lumen
- extracellular exosome
- recycling endosome membrane
- MHC class I peptide loading complex
- MHC class II protein complex
- MHC class I protein complex
- specific granule lumen
- early endosome lumen
- late endosome membrane
- early endosome membrane
- phagocytic vesicle membrane
- membrane
- ER to Golgi transport vesicle membrane
- cell surface
- external side of plasma membrane
- focal adhesion
- plasma membrane
- cytosol
- Golgi apparatus
- endoplasmic reticulum lumen
- endoplasmic reticulum
- lysosomal membrane
- extracellular space
- extracellular region
- Golgi membrane
Sequence families
Protein families (Pfam)
![The deposited structure of PDB entry 5d2l contains 4 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain Q [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/5d2l_2_D_Pfam_PF07654_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5d2l</span> contains 4 copies of Pfam domain <span class='highlight'>PF07654 (Immunoglobulin C1-set domain)</span> in <span class='highlight'>Beta-2-microglobulin</span>. Showing 1 copy in chain <span class='highlight'>Q [auth D]</span>.")
InterPro annotations
IPR003006
Domain description:
Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
Occurring in:
Structure domains
CATH domains
2.60.40.10
Class:
Mainly Beta
Architecture:
Sandwich
Topology:
Immunoglobulin-like
Homology:
Immunoglobulins
Occurring in:
![The deposited structure of PDB entry 5d2l contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain Q [auth D].](https://www.ebi.ac.uk/pdbe/static/entry/5d2l_2_D_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5d2l</span> contains 4 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>Beta-2-microglobulin</span>. Showing 1 copy in chain <span class='highlight'>Q [auth D]</span>.")
![The deposited structure of PDB entry 5d2l contains 8 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in C7 TCR alpha chain. Showing 2 copies in chain H [auth K].](https://www.ebi.ac.uk/pdbe/static/entry/5d2l_3_K_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5d2l</span> contains 8 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>C7 TCR alpha chain</span>. Showing 2 copies in chain <span class='highlight'>H [auth K]</span>.")
![The deposited structure of PDB entry 5d2l contains 8 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in C7 TCR beta chain. Showing 2 copies in chain S [auth F].](https://www.ebi.ac.uk/pdbe/static/entry/5d2l_4_F_CATH_2.60.40.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>5d2l</span> contains 8 copies of CATH domain <span class='highlight'>2.60.40.10 (Immunoglobulin-like)</span> in <span class='highlight'>C7 TCR beta chain</span>. Showing 2 copies in chain <span class='highlight'>S [auth F]</span>.")
