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Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768

X-ray diffraction
2.1Å resolution
PDB entry 5d2d coloured by chain, front view.
PDB entry 5d2d coloured by chain, side view.
PDB entry 5d2d coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cystic fibrosis transmembrane conductance regulator and 14-3-3 protein zeta/delta
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Multimeric state: hetero trimer
Accessible surface area: 22353.72 Å2
Buried surface area: 6190.47 Å2
Dissociation area: 1,433.02 Å2
Dissociation energy (ΔGdiss): 17.12 kcal/mol
Dissociation entropy (TΔSdiss): 12.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146642

Macromolecules

14-3-3 protein zeta/delta
Chains: A, B
Length: 230 amino acids
Theoretical weight: 26.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63104 (Residues: 1-230; Coverage: 94%)
Gene name: YWHAZ
Pfam: 14-3-3 protein
InterPro:
CATH: 14-3-3 domain
14-3-3 protein zeta/delta in PDB entry 5d2d, assembly 1, front view.
14-3-3 protein zeta/delta in PDB entry 5d2d, assembly 1, side view.
14-3-3 protein zeta/delta in PDB entry 5d2d, assembly 1, top view.
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Cystic fibrosis transmembrane conductance regulator
Chain: C
Length: 28 amino acids
Theoretical weight: 3.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13569 (Residues: 747-774; Coverage: 2%)
Gene names: ABCC7, CFTR
InterPro: CFTR regulator domain
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d2d, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d2d, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 5d2d, assembly 1, top view.
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