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Crystal structure of CK2alpha bound to CAM4066

X-ray diffraction
1.787Å resolution
PDB entry 5cu3 coloured by chain, front view.
PDB entry 5cu3 coloured by chain, side view.
PDB entry 5cu3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Casein kinase II subunit alpha
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Multimeric state: homo dimer
Accessible surface area: 29357.17 Å2
Buried surface area: 2714.5 Å2
Dissociation area: 645.85 Å2
Dissociation energy (ΔGdiss): -9.4 kcal/mol
Dissociation entropy (TΔSdiss): 13.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159392

Macromolecules

Casein kinase II subunit alpha
Chains: A, B
Length: 352 amino acids
Theoretical weight: 41.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68400 (Residues: 2-329; Coverage: 84%)
Gene names: CK2A1, CSNK2A1
Pfam: Protein kinase domain
InterPro:
CATH:
Casein kinase II subunit alpha in PDB entry 5cu3, assembly 1, front view.
Casein kinase II subunit alpha in PDB entry 5cu3, assembly 1, side view.
Casein kinase II subunit alpha in PDB entry 5cu3, assembly 1, top view.
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