PDB 5ctp biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1

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Assembly Name: Casein kinase II subunit alpha
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Multimeric state: monomeric

Accessible surface area: 15588.92 Å²

Buried surface area: 244.51 Å²

Dissociation area: 122.25 Å²

Dissociation energy (ΔG^diss): 2.81 kcal/mol

Dissociation entropy (TΔS^diss): -0.31 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-159383

$Monomeric assembly 1 of PDB entry 5ctp coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5ctp coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 5ctp coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>1 copy of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2 (preferred)

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Assembly Name: Casein kinase II subunit alpha
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Multimeric state: monomeric

Accessible surface area: 15841.55 Å²

Buried surface area: 715.16 Å²

Dissociation area: 43.38 Å²

Dissociation energy (ΔG^diss): 0.04 kcal/mol

Dissociation entropy (TΔS^diss): -0.35 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-159383

$Monomeric assembly 2 of PDB entry 5ctp coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>3 copies of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of PHOSPHATE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 5ctp coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>3 copies of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of PHOSPHATE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 5ctp coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Casein kinase II subunit alpha;</li> <li class='image_legend_li'>3 copies of ACETATE ION;</li> <li class='image_legend_li'>1 copy of N-(3-{[(2-chlorobiphenyl-4-yl)methyl]amino}propyl)acetamide;</li> <li class='image_legend_li'>1 copy of PHOSPHATE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Casein kinase II subunit alpha

Chains: A, B
Length: 352 amino acids
Theoretical weight: 41.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:

Canonical: P68400 (Residues: 2-329; Coverage: 84%)

Gene names: CK2A1, CSNK2A1
Pfam: Protein kinase domain
InterPro:

Casein Kinase 2, subunit alpha
Protein kinase-like domain superfamily
Protein kinase domain
Protein kinase, ATP binding site
Serine/threonine-protein kinase, active site

CATH:

Transferase(Phosphotransferase) domain 1
Phosphorylase Kinase; domain 1

Casein kinase II subunit alpha in PDB entry 5ctp, assembly 2, front view.

Casein kinase II subunit alpha in PDB entry 5ctp, assembly 2, side view.

Casein kinase II subunit alpha in PDB entry 5ctp, assembly 2, top view.

FASTA Sequence


    >pdb|5ctp|A B

GSMDIEFDDDADDDGSGSGSGSGSSGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK

PDBe-KB: UniProt Coverage View: P68400

Molecule details ›

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FASTA (Protein chains A, B)
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PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
Similar sequences

BLAST P68400 (UniProt)

Protein Data Bank in Europe

Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

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Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

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PDBe › 5ctp › Structure analysis

Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound

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Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

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5ctp › Structure analysis