Function and Biology Details
Reaction catalysed:
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ribonucleotide reductase large subunit, C-terminal
- Ribonucleotide reductase small subunit family
- Ribonucleotide reductase, class I, alpha subunit, C-terminal
- ATP-cone domain
- Ribonucleotide reductase small subunit, acitve site
- Ribonucleotide reductase small subunit
- Ferritin-like superfamily
- Ribonucleotide reductase-like
3 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Ribonucleoside-diphosphate reductase 1 (preferred)
PDBe Complex ID:
PDB-CPX-132531 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ribonucleoside-diphosphate reductase 1 subunit alpha
Molecule details ›
Chains: A, B, C, D
Length: 761 amino acids
Theoretical weight: 85.88 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Length: 761 amino acids
Theoretical weight: 85.88 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical:
P00452 (Residues: 1-761; Coverage: 100%)
Sequence domains:
Structure domains: Anaerobic Ribonucleotide-triphosphate Reductase Large Chain
Ribonucleoside-diphosphate reductase 1 subunit beta
Molecule details ›
Chains: E, F, G, H
Length: 375 amino acids
Theoretical weight: 43.43 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains: Ribonucleotide reductase, small chain
Structure domains: Ribonucleotide Reductase, subunit A
Length: 375 amino acids
Theoretical weight: 43.43 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical: P69924 (Residues: 2-376; Coverage: 100%)
Sequence domains: Ribonucleotide reductase, small chain
Structure domains: Ribonucleotide Reductase, subunit A
