› 5cno

X-ray diffraction
1.55Å resolution

Crystal structure of the EGFR kinase domain mutant V924R

Released:
DOI: 10.2210/pdb5cno/pdb
PDB entry 5cno coloured by chain, front view.
PDB entry 5cno coloured by chain, side view.
PDB entry 5cno coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J
Mol Cell Biol 35 3083-102 (2015)
PMID: 26124280

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B, X
Molecule details ›
Chains: A, B, X
Length: 330 amino acids
Theoretical weight: 37.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2
Unit cell:
a: 155.4Å b: 71.837Å c: 76.399Å
α: 90° β: 113.27° γ: 90°
R-values:
R R work R free
0.176 0.175 0.203
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.
Black et al. (2019)
8 more

11 mentions without citation

More than the sum of the parts: Toward full-length receptor tyrosine kinase structures.
Diwanji et al. (2019)
10 more