PDBe 5ceq

X-ray diffraction
1.91Å resolution

DLK in complex with inhibitor 2-((1-cyclopentyl-5-(1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-3-yl)amino)isonicotinonitrile

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 12 Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q12852 (Residues: 115-402; Coverage: 34%)
Gene names: MAP3K12, ZPK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 57.404Å b: 39.223Å c: 59.815Å
α: 90° β: 104.8° γ: 90°
R-values:
R R work R free
0.171 0.169 0.218
Expression system: Trichoplusia ni