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Crystal structure of DLK (kinase domain)

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.11.25: Mitogen-activated protein kinase kinase kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (MAPKKKK-activated)
Alternative Name(s):
  • CMos
  • CRaf
  • MAP kinase kinase kinase
  • MAP3K
  • MAPKKK
  • MEK kinase
  • MEKK
  • MEKK1
  • MEKK2
  • MEKK3
  • MLK-like mitogen-activated protein triple kinase
  • MLTK
  • MLTKa
  • MLTKb
  • Mil/Raf
  • REKS
  • STK28

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF07714
Domain description: Protein tyrosine and serine/threonine kinase
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
The deposited structure of PDB entry 5cen contains 1 copy of Pfam domain PF07714 (Protein tyrosine and serine/threonine kinase) in Mitogen-activated protein kinase kinase kinase 12. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001245
Domain description: Serine-threonine/tyrosine-protein kinase, catalytic domain
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
The deposited structure of PDB entry 5cen contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Mitogen-activated protein kinase kinase kinase 12. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Mitogen-activated protein kinase kinase kinase 12
The deposited structure of PDB entry 5cen contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Mitogen-activated protein kinase kinase kinase 12. Showing 1 copy in chain A.

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