› 5cc5

X-ray diffraction
2.14Å resolution

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-3-carboxylic acid

Released:
DOI: 10.2210/pdb5cc5/pdb
PDB entry 5cc5 coloured by chain, front view.
PDB entry 5cc5 coloured by chain, side view.
PDB entry 5cc5 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Huang H-L, Sacchettini JC

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malate synthase G Chain: A
Molecule details ›
Chain: A
Length: 741 amino acids
Theoretical weight: 80.46 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WK17 (Residues: 1-741; Coverage: 100%)
Gene names: MTCY1A11.06, Rv1837c, glcB
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand GLV 1 x GLV
Ligand ICO 1 x ICO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P43212
Unit cell:
a: 79.699Å b: 79.699Å c: 223.304Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.168 0.217
Expression system: Escherichia coli BL21

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