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Crystal Structure of Conjoint Pyrococcus furiosus L-asparaginase at 37 degree C

Source organism: Pyrococcus furiosus DSM 3638
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 3.5.1.1: Asparaginase

Reaction catalysed:
L-asparagine + H(2)O = L-aspartate + NH(3)
Systematic name:
L-asparagine amidohydrolase
Alternative Name(s):
  • Alpha-asparaginase
  • Asparaginase II
  • Colaspase
  • Crasnitin
  • Elspar
  • L-asparaginase
  • Leunase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF17763
Domain description: Glutaminase/Asparaginase C-terminal domain
Occurring in:
  1. L-asparaginase
The deposited structure of PDB entry 5cbp contains 1 copy of Pfam domain PF17763 (Glutaminase/Asparaginase C-terminal domain) in L-asparaginase. Showing 1 copy in chain B.

PF00710
Domain description: Asparaginase, N-terminal
Occurring in:
  1. L-asparaginase
The deposited structure of PDB entry 5cbp contains 1 copy of Pfam domain PF00710 (Asparaginase, N-terminal) in L-asparaginase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006034
Domain description: Asparaginase/glutaminase-like
Occurring in:
  1. L-asparaginase
  2. L-asparaginase
IPR036152
Domain description: Asparaginase/glutaminase-like superfamily
Occurring in:
  1. L-asparaginase
  2. L-asparaginase
IPR040919
Domain description: Asparaginase/glutaminase, C-terminal
Occurring in:
  1. L-asparaginase
IPR027473
Domain description: L-asparaginase, C-terminal
Occurring in:
  1. L-asparaginase
IPR027475
Domain description: Asparaginase/glutaminase, active site 2
Occurring in:
  1. L-asparaginase
IPR027474
Domain description: L-asparaginase, N-terminal
Occurring in:
  1. L-asparaginase
IPR041725
Domain description: Type I (cytosolic) L-asparaginase
Occurring in:
  1. L-asparaginase
IPR037152
Domain description: L-asparaginase, N-terminal domain superfamily
Occurring in:
  1. L-asparaginase

Structure domains

CATH CATH domains
3.40.50.40
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. L-asparaginase
The deposited structure of PDB entry 5cbp contains 1 copy of CATH domain 3.40.50.40 (Rossmann fold) in L-asparaginase. Showing 1 copy in chain B.
3.40.50.1170
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: L-asparaginase, N-terminal domain
Occurring in:
  1. L-asparaginase
The deposited structure of PDB entry 5cbp contains 1 copy of CATH domain 3.40.50.1170 (Rossmann fold) in L-asparaginase. Showing 1 copy in chain A.

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