› 5c9b

X-ray diffraction
2.4Å resolution

Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii

Released:
DOI: 10.2210/pdb5c9b/pdb
PDB entry 5c9b coloured by chain, front view.
PDB entry 5c9b coloured by chain, side view.
PDB entry 5c9b coloured by chain, top view.
Source organism: Rickettsia conorii
Primary publication:
Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Li M, Gustchina A, Cruz R, Simões M, Curto P, Martinez J, Faro C, Simões I, Wlodawer A
Acta Crystallogr D Biol Crystallogr 71 2109-18 (2015)
PMID: 26457434

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aspartyl protease Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 139 amino acids
Theoretical weight: 15.86 KDa
Source organism: Rickettsia conorii
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92FY8 (Residues: 105-231; Coverage: 55%)
Gene name: RC1339
Sequence domains: gag-polyprotein putative aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P3221
Unit cell:
a: 101.985Å b: 101.985Å c: 127.063Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.199 0.262
Expression system: Escherichia coli BL21(DE3)

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Citations

4 citation in other articles

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans.
Leal et al. (2016)
3 more

1 mention without citation

Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Li et al. (2015)