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Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.

Wang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, Lai Q, Yang Z, Chen Q, Yang J
FEBS J 283 102-11 (2016)
Related entries: 5ca0, 5ca1, 5cb4

Cited: 92 times
EuropePMC logo PMID: 26462166

Reviews - 5c8y mentioned but not cited (2)

  1. Bioactive pyrrole-based compounds with target selectivity. Li Petri G, Spanò V, Spatola R, Holl R, Raimondi MV, Barraja P, Montalbano A. Eur J Med Chem 208 112783 (2020)
  2. Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective. Wang J, Miller DD, Li W. Drug Discov Today 27 759-776 (2022)

Articles - 5c8y mentioned but not cited (13)

  1. Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Wang Y, Zhang H, Gigant B, Yu Y, Wu Y, Chen X, Lai Q, Yang Z, Chen Q, Yang J. FEBS J 283 102-111 (2016)
  2. Mechanism of microtubule stabilization by taccalonolide AJ. Wang Y, Yu Y, Li GB, Li SA, Wu C, Gigant B, Qin W, Chen H, Wu Y, Chen Q, Yang J. Nat Commun 8 15787 (2017)
  3. A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity. Sirakanyan S, Arabyan E, Hakobyan A, Hakobyan T, Chilingaryan G, Sahakyan H, Sargsyan A, Arakelov G, Nazaryan K, Izmailyan R, Abroyan L, Karalyan Z, Arakelova E, Hakobyan E, Hovakimyan A, Serobian A, Neves M, Ferreira J, Ferreira F, Zakaryan H. Emerg Microbes Infect 10 783-796 (2021)
  4. Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents. Carta D, Bortolozzi R, Sturlese M, Salmaso V, Hamel E, Basso G, Calderan L, Quintieri L, Moro S, Viola G, Ferlin MG. Eur J Med Chem 127 643-660 (2017)
  5. In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K. Emery-Corbin SJ, Su Q, Tichkule S, Baker L, Lacey E, Jex AR. Int J Parasitol Drugs Drug Resist 16 162-173 (2021)
  6. Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs. Bortolozzi R, Mattiuzzo E, Dal Pra M, Sturlese M, Moro S, Hamel E, Carta D, Viola G, Ferlin MG. Eur J Med Chem 143 244-258 (2018)
  7. Molecular modelling and de novo fragment-based design of potential inhibitors of beta-tubulin gene of Necator americanus from natural products. Agyapong O, Asiedu SO, Kwofie SK, Miller WA, Parry CS, Sowah RA, Wilson MD. Inform Med Unlocked 26 100734 (2021)
  8. Biological activity and interaction mechanism of the diketopiperazine derivatives as tubulin polymerization inhibitors. Tian Z, Chu Y, Wang H, Zhong L, Deng M, Li W. RSC Adv 8 1055-1064 (2018)
  9. Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function. Oliva MÁ, Tosat-Bitrián C, Barrado-Gil L, Bonato F, Galindo I, Garaigorta U, Álvarez-Bernad B, París-Ogáyar R, Lucena-Agell D, Giménez-Abián JF, García-Dorival I, Urquiza J, Gastaminza P, Díaz JF, Palomo V, Alonso C. Int J Mol Sci 23 3448 (2022)
  10. Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity. Kirchner S, Leistner AL, Gödtel P, Seliwjorstow A, Weber S, Karcher J, Nieger M, Pianowski Z. Nat Commun 13 6066 (2022)
  11. Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy. Ding Z, Li F, Xie L, Gu M, Li C, Liu C, Peng C, Li W. Mar Drugs 20 752 (2022)
  12. Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Steinlein S, Essmann F, Ghilardi AF, Horn H, Schüler J, Hausser A, Sun L, Ott G, Kalla C. Front Oncol 13 1190988 (2023)
  13. PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. Lucena-Agell D, Guillén MJ, Matesanz R, Álvarez-Bernad B, Hortigüela R, Avilés P, Martínez-Díez M, Santamaría-Núñez G, Contreras J, Plaza-Menacho I, Giménez-Abián JF, Oliva MA, Cuevas C, Díaz JF. J Med Chem 67 2619-2630 (2024)


Reviews citing this publication (8)

  1. Non-kinase targets of protein kinase inhibitors. Munoz L. Nat Rev Drug Discov 16 424-440 (2017)
  2. Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy. Arnst KE, Banerjee S, Chen H, Deng S, Hwang DJ, Li W, Miller DD. Med Res Rev 39 1398-1426 (2019)
  3. Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures. Li W, Sun H, Xu S, Zhu Z, Xu J. Future Med Chem 9 1765-1794 (2017)
  4. Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress? Georgakilas AG, Tsantoulis P, Kotsinas A, Michalopoulos I, Townsend P, Gorgoulis VG. Cell Mol Life Sci 71 4519-4544 (2014)
  5. Lessons from bacterial homolog of tubulin, FtsZ for microtubule dynamics. Battaje RR, Panda D. Endocr Relat Cancer 24 T1-T21 (2017)
  6. Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target. Vicente-Blázquez A, González M, Álvarez R, Del Mazo S, Medarde M, Peláez R. Med Res Rev 39 775-830 (2019)
  7. Improving Homology-Directed Repair in Genome Editing Experiments by Influencing the Cell Cycle. Smirnikhina SA, Zaynitdinova MI, Sergeeva VA, Lavrov AV. Int J Mol Sci 23 5992 (2022)
  8. The microtubule cytoskeleton: An old validated target for novel therapeutic drugs. Lafanechère L. Front Pharmacol 13 969183 (2022)

Articles citing this publication (69)

  1. Revisiting Activity of Some Nocodazole Analogues as a Potential Anticancer Drugs Using Molecular Docking and DFT Calculations. Khattab M, Al-Karmalawy AA. Front Chem 9 628398 (2021)
  2. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. Banerjee S, Arnst KE, Wang Y, Kumar G, Deng S, Yang L, Li GB, Yang J, White SW, Li W, Miller DD. J Med Chem 61 1704-1718 (2018)
  3. Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents. Richter M, Boldescu V, Graf D, Streicher F, Dimoglo A, Bartenschlager R, Klein CD. ChemMedChem 14 469-483 (2019)
  4. Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site. Matthew S, Chen QY, Ratnayake R, Fermaintt CS, Lucena-Agell D, Bonato F, Prota AE, Lim ST, Wang X, Díaz JF, Risinger AL, Paul VJ, Oliva MÁ, Luesch H. Proc Natl Acad Sci U S A 118 e2021847118 (2021)
  5. Hemithioindigos for Cellular Photopharmacology: Desymmetrised Molecular Switch Scaffolds Enabling Design Control over the Isomer-Dependency of Potent Antimitotic Bioactivity. Sailer A, Ermer F, Kraus Y, Lutter FH, Donau C, Bremerich M, Ahlfeld J, Thorn-Seshold O. Chembiochem 20 1305-1314 (2019)
  6. Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin. Chen GY, Cleary JM, Asenjo AB, Chen Y, Mascaro JA, Arginteanu DFJ, Sosa H, Hancock WO. Curr Biol 29 2259-2269.e4 (2019)
  7. Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity. Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L. J Biol Chem 294 18099-18108 (2019)
  8. High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM. Sci Rep 8 4242 (2018)
  9. Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling. Cimino PJ, Huang L, Du L, Wu Y, Bishop J, Dalsing-Hernandez J, Kotlarczyk K, Gonzales P, Carew J, Nawrocki S, Jordan MA, Wilson L, Lloyd GK, Wirsching HG. Biomed Rep 10 218-224 (2019)
  10. β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells. Malebari AM, Greene LM, Nathwani SM, Fayne D, O'Boyle NM, Wang S, Twamley B, Zisterer DM, Meegan MJ. Eur J Med Chem 130 261-285 (2017)
  11. Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities. Wang Q, Arnst KE, Wang Y, Kumar G, Ma D, Chen H, Wu Z, Yang J, White SW, Miller DD, Li W. J Med Chem 61 7877-7891 (2018)
  12. Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase-3 activation activities. Abdelbaset MS, Abdel-Aziz M, Abuo-Rahma GEA, Abdelrahman MH, Ramadan M, Youssif BGM. Arch Pharm (Weinheim) 352 e1800270 (2019)
  13. Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508. Xu JL, Liu HX, Chen YC, Tan HB, Guo H, Xu LQ, Li SN, Huang ZL, Li HH, Gao XX, Zhang WM. Mar Drugs 16 E329 (2018)
  14. Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1. Patel O, Roy MJ, Kropp A, Hardy JM, Dai W, Lucet IS. Commun Biol 4 1105 (2021)
  15. Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE. Nolasco S, Bellido J, Serna M, Carmona B, Soares H, Zabala JC. Front Cell Dev Biol 9 656273 (2021)
  16. Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties. Gilson P, Josa-Prado F, Beauvineau C, Naud-Martin D, Vanwonterghem L, Mahuteau-Betzer F, Moreno A, Falson P, Lafanechère L, Frachet V, Coll JL, Fernando Díaz J, Hurbin A, Busser B. Sci Rep 7 10209 (2017)
  17. Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization. Niu H, Strecker TE, Gerberich JL, Campbell JW, Saha D, Mondal D, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. J Med Chem 62 5594-5615 (2019)
  18. X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. Banerjee S, Mahmud F, Deng S, Ma L, Yun MK, Fakayode SO, Arnst KE, Yang L, Chen H, Wu Z, Lukka PB, Parmar K, Meibohm B, White SW, Wang Y, Li W, Miller DD. J Med Chem 64 13072-13095 (2021)
  19. A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo. Wu YW, Hsu KC, Lee HY, Huang TC, Lin TE, Chen YL, Sung TY, Liou JP, Hwang-Verslues WW, Pan SL, HuangFu WC. Front Pharmacol 9 205 (2018)
  20. Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Gaillard N, Sharma A, Abbaali I, Liu T, Shilliday F, Cook AD, Ehrhard V, Bangera M, Roberts AJ, Moores CA, Morrissette N, Steinmetz MO. EMBO Mol Med 13 e13818 (2021)
  21. Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents. Abbassi RH, Recasens A, Indurthi DC, Johns TG, Stringer BW, Day BW, Munoz L. ACS Pharmacol Transl Sci 2 402-413 (2019)
  22. Plinabulin ameliorates neutropenia induced by multiple chemotherapies through a mechanism distinct from G-CSF therapies. Tonra JR, Lloyd GK, Mohanlal R, Huang L. Cancer Chemother Pharmacol 85 461-468 (2020)
  23. Structure-Based Pharmacophore Design and Virtual Screening for Novel Tubulin Inhibitors with Potential Anticancer Activity. Zhou Y, Di B, Niu MM. Molecules 24 E3181 (2019)
  24. Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors. Gallego-Yerga L, Ochoa R, Lans I, Peña-Varas C, Alegría-Arcos M, Cossio P, Ramírez D, Peláez R. Comput Struct Biotechnol J 19 4360-4372 (2021)
  25. Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents. Zhou Y, Yan W, Cao D, Shao M, Li D, Wang F, Yang Z, Chen Y, He L, Wang T, Shen M, Chen L. Eur J Med Chem 138 1114-1125 (2017)
  26. Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β-Tubulin. Guzmán-Ocampo DC, Aguayo-Ortiz R, Cano-González L, Castillo R, Hernández-Campos A, Dominguez L. ChemMedChem 13 20-24 (2018)
  27. In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand. Pallante L, Rocca A, Klejborowska G, Huczynski A, Grasso G, Tuszynski JA, Deriu MA. Front Chem 8 108 (2020)
  28. Aberrant RON and MET Co-overexpression as Novel Prognostic Biomarkers of Shortened Patient Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Pancreatic Cancer. Hu CY, Xu XM, Hong B, Wu ZG, Qian Y, Weng TH, Liu YZ, Tang TM, Wang MH, Yao HP. Front Oncol 9 1377 (2019)
  29. Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors. Aguayo-Ortiz R, Cano-González L, Castillo R, Hernández-Campos A, Dominguez L. Chem Biol Drug Des 90 40-51 (2017)
  30. Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4. Malebari AM, Wang S, Greene TF, O'Boyle NM, Fayne D, Khan MF, Nathwani SM, Twamley B, McCabe T, Zisterer DM, Meegan MJ. Pharmaceuticals (Basel) 14 1119 (2021)
  31. Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy. Arnst KE, Wang Y, Lei ZN, Hwang DJ, Kumar G, Ma D, Parke DN, Chen Q, Yang J, White SW, Seagroves TN, Chen ZS, Miller DD, Li W. Mol Pharmacol 96 73-89 (2019)
  32. Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3). Gargantilla M, Persoons L, Kauerová T, Del Río N, Daelemans D, Priego EM, Kollar P, Pérez-Pérez MJ. Pharmaceuticals (Basel) 15 835 (2022)
  33. Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin. Sharma A, Sáez-Calvo G, Olieric N, de Asís Balaguer F, Barasoain I, Lamberth C, Díaz JF, Steinmetz MO. Int J Mol Sci 18 E1336 (2017)
  34. Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001. Youssef DTA, Shaala LA, Genta-Jouve G. Mar Drugs 20 451 (2022)
  35. Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. Garge RK, Cha HJ, Lee C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM. Genetics 219 iyab101 (2021)
  36. Insight into microtubule destabilization mechanism of 3,4,5-trimethoxyphenyl indanone derivatives using molecular dynamics simulation and conformational modes analysis. Tripathi S, Srivastava G, Singh A, Prakasham AP, Negi AS, Sharma A. J Comput Aided Mol Des 32 559-572 (2018)
  37. A novel piperazine linked β-amino alcohols bearing a benzosuberone scaffolds as anti-proliferative agents. Vanguru S, Jilla L, Sajja Y, Bantu R, Nagarapu L, Nanubolu JB, Bhaskar B, Jain N, Sivan S, Manga V. Bioorg Med Chem Lett 27 792-796 (2017)
  38. Characterization of Microtubule Destabilizing Drugs: A Quantitative Cell-Based Assay That Bridges the Gap between Tubulin Based- and Cytotoxicity Assays. Laisne MC, Michallet S, Lafanechère L. Cancers (Basel) 13 5226 (2021)
  39. Synthesis, Biological Evaluation, and Molecular Modeling Studies of 1-Aryl-1H-pyrazole-Fused Curcumin Analogues as Anticancer Agents. Doan NQH, Nguyen NTK, Duong VB, Nguyen HTT, Vong LB, Duong DN, Nguyen NT, Nguyen TLT, Do TTH, Truong TN. ACS Omega 7 33963-33984 (2022)
  40. Synthesis, Characterisation and Mechanism of Action of Anticancer 3-Fluoroazetidin-2-ones. Malebari AM, Duffy Morales G, Twamley B, Fayne D, Khan MF, McLoughlin EC, O'Boyle NM, Zisterer DM, Meegan MJ. Pharmaceuticals (Basel) 15 1044 (2022)
  41. Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents. Gallego-Yerga L, Ceña V, Peláez R. Pharmaceutics 15 1698 (2023)
  42. Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, Barasoain I, Song C, Sun D, Dovat S, Yunes RA, Prota AE, Steinmetz MO, Díaz JF, Yunes JA. iScience 21 95-109 (2019)
  43. Anti-Tumoral Effects of a (1H-Pyrrol-1-yl)Methyl-1H-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines. Nicolai A, Madia VN, Messore A, De Vita D, De Leo A, Ialongo D, Tudino V, Tortorella E, Scipione L, Taurone S, Pergolizzi T, Artico M, Di Santo R, Costi R, Scarpa S. Pharmaceuticals (Basel) 14 564 (2021)
  44. Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors. Mangiatordi GF, Trisciuzzi D, Iacobazzi R, Denora N, Pisani L, Catto M, Leonetti F, Alberga D, Nicolotti O. Chem Biol Drug Des 92 1161-1170 (2018)
  45. Benzotriazole Substituted 2-Phenylquinazolines as Anticancer Agents: Synthesis, Screening, Antiproliferative and Tubulin Polymerization Inhibition Activity. Dwivedi AR, Rawat SS, Kumar V, Kumar N, Kumar V, Yadav RP, Baranwal S, Prasad A, Kumar V. Curr Cancer Drug Targets 23 278-292 (2023)
  46. Biological Evaluation in Vitro and in Silico of Azetidin-2-one Derivatives as Potential Anticancer Agents. Olazaran FE, Rivera G, Pérez-Vázquez AM, Morales-Reyes CM, Segura-Cabrera A, Balderas-Rentería I. ACS Med Chem Lett 8 32-37 (2017)
  47. Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells. Jaunky DB, Larocque K, Husser MC, Liu JT, Forgione P, Piekny A. Sci Rep 11 23665 (2021)
  48. Computational Prediction and Experimental Validation of the Unique Molecular Mode of Action of Scoulerine. Moshari M, Wang Q, Michalak M, Klobukowski M, Tuszynski JA. Molecules 27 3991 (2022)
  49. Design, synthesis and biological evaluation of a novel colchicine-magnolol hybrid for inhibiting the growth of Lewis lung carcinoma in Vitro and in Vivo. Li Z, Hu S, Pu LY, Li Z, Zhu G, Cao Y, Li L, Ma Y, Liu Z, Li X, Liu G, Chen K, Wu Z. Front Chem 10 1094019 (2022)
  50. Exploring Pyrrolo-Fused Heterocycles as Promising Anticancer Agents: An Integrated Synthetic, Biological, and Computational Approach. Amărandi RM, Al-Matarneh MC, Popovici L, Ciobanu CI, Neamțu A, Mangalagiu II, Danac R. Pharmaceuticals (Basel) 16 865 (2023)
  51. Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation. Wang L, Xu K, Wang N, Ding L, Zhao W, Wan R, Zhao W, Guo X, Pan X, Yang J, Rosas I, Yu G. Int J Mol Sci 23 14088 (2022)
  52. From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin. Copmans D, Kildgaard S, Roux E, Partoens M, Steurs G, Wang X, De Borggraeve WM, Esguerra CV, Crawford AD, Larsen TO, de Witte PAM. Pharmaceuticals (Basel) 15 247 (2022)
  53. Modulation Effect on Tubulin Polymerization, Cytotoxicity and Antioxidant Activity of 1H-Benzimidazole-2-Yl Hydrazones. Argirova M, Guncheva M, Momekov G, Cherneva E, Mihaylova R, Rangelov M, Todorova N, Denev P, Anichina K, Mavrova A, Yancheva D. Molecules 28 291 (2022)
  54. Pyridachlometyl has a novel anti-tubulin mode of action which could be useful in anti-resistance management. Matsuzaki Y, Watanabe S, Harada T, Iwahashi F. Pest Manag Sci 76 1393-1401 (2020)
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  57. Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis. Su Q, Baker L, Emery S, Balan B, Ansell B, Tichkule S, Mueller I, Svärd SG, Jex A. Int J Parasitol Drugs Drug Resist 22 9-19 (2023)
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  60. Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells. Wang S, Malebari AM, Greene TF, Kandwal S, Fayne D, Nathwani SM, Zisterer DM, Twamley B, O'Boyle NM, Meegan MJ. Pharmaceuticals (Basel) 16 1000 (2023)
  61. Effect of Colchicine Binding Site Inhibitors on the Tubulin Intersubunit Interaction. Sargsyan A, Sahakyan H, Nazaryan K. ACS Omega 8 29448-29454 (2023)
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  63. Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition. Ramos S, Vicente-Blázquez A, López-Rubio M, Gallego-Yerga L, Álvarez R, Peláez R. Int J Mol Sci 24 17474 (2023)
  64. Identification of Novel β-Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach. Horgan MJ, Zell L, Siewert B, Stuppner H, Schuster D, Temml V. J Chem Inf Model 63 6396-6411 (2023)
  65. Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris β-tubulins by molecular docking simulations. Jones BP, van Vliet AHM, LaCourse EJ, Betson M. Sci Rep 12 13725 (2022)
  66. Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells. Kesel AJ. Molecules 29 914 (2024)
  67. Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling. El-Kalyoubi S, El-Sebaey SA, El-Sayed AA, Abdelhamid MS, Agili F, Elfeky SM. J Enzyme Inhib Med Chem 38 2232125 (2023)
  68. RepoMan stimulates the chromosome-dependent pathway of microtubule assembly. De Munter S, Van der Hoeven G, Bollen M. Cell Cycle 19 3029-3041 (2020)
  69. Synthesis and Anticancer Activity of Mitotic-Specific 3,4-Dihydropyridine-2(1H)-thiones. Perużyńska M, Borzyszkowska-Ledwig A, Sośnicki JG, Struk Ł, Idzik TJ, Maciejewska G, Skalski Ł, Piotrowska K, Łukasik P, Droździk M, Kurzawski M. Int J Mol Sci 22 2462 (2021)


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