Function and Biology

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: DNA biosynthetic process
Cellular component: gamma DNA polymerase complex

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

Sequence families

Pfam Protein families (Pfam)
PF03129
Domain description: Anticodon binding domain
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
1 copy of Pfam domain PF03129 (Anticodon binding domain) in DNA polymerase subunit gamma-2, mitochondrial in PDB 5c52.

PF00476
Domain description: DNA polymerase family A
Occurring in:
  1. DNA polymerase subunit gamma-1
1 copy of Pfam domain PF00476 (DNA polymerase family A) in DNA polymerase subunit gamma-1 in PDB 5c52.

PF18136
Domain description: DNA mitochondrial polymerase exonuclease domain
Occurring in:
  1. DNA polymerase subunit gamma-1
1 copy of Pfam domain PF18136 (DNA mitochondrial polymerase exonuclease domain) in DNA polymerase subunit gamma-1 in PDB 5c52.

InterPro InterPro annotations
IPR002297
Domain description: DNA-directed DNA-polymerase, family A, mitochondria
Occurring in:
  1. DNA polymerase subunit gamma-1
IPR001098
Domain description: DNA-directed DNA polymerase, family A, palm domain
Occurring in:
  1. DNA polymerase subunit gamma-1
IPR027031
Domain description: Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
IPR027030
Domain description: DNA polymerase subunit gamma-2, mitochondrial
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
IPR042064
Domain description: POLG2, C-terminal
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
IPR036621
Domain description: Anticodon-binding domain superfamily
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
IPR004154
Domain description: Anticodon-binding
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. DNA polymerase subunit gamma-1
IPR041336
Domain description: DNA mitochondrial polymerase, exonuclease domain
Occurring in:
  1. DNA polymerase subunit gamma-1

Structure domains

CATH CATH domains
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
1 copy of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in DNA polymerase subunit gamma-2, mitochondrial in PDB 5c52.
3.40.50.800
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Anticodon-binding domain
Occurring in:
  1. DNA polymerase subunit gamma-2, mitochondrial
1 copy of CATH domain 3.40.50.800 (Rossmann fold) in DNA polymerase subunit gamma-2, mitochondrial in PDB 5c52.