Structure analysis

Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase gamma

X-ray diffraction
3.637Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 85500 Å2
Buried surface area: 17400 Å2
Dissociation area: 2,300 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -83 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 1205 amino acids
Theoretical weight: 135.99 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: P54098 (Residues: 25-1239; Coverage: 97%)
Gene names: MDP1, POLG, POLG1, POLGA
Pfam:
InterPro:

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Chains: B, C
Length: 485 amino acids
Theoretical weight: 54.98 KDa
Source organism: Homo sapiens
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: Q9UHN1 (Residues: 1-485; Coverage: 100%)
Gene names: MTPOLB, POLG2
Pfam: Anticodon binding domain
InterPro:
CATH:

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Name: DNA (26-MER)
Representative chains: T
Length: 26 nucleotides
Theoretical weight: 7.96 KDa

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Name: DNA (5'-D(*AP*AP*AP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3')
Representative chains: P
Length: 22 nucleotides
Theoretical weight: 6.78 KDa

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