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Crystal structure of GTB + UDP-Glc + H-antigen acceptor

Source organism: Homo sapiens
Biochemical function: hexosyltransferase activity
Biological process: carbohydrate metabolic process
Cellular component: membrane

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EC 2.4.1.40: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase

Reaction catalysed:
UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose
Systematic name:
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Alternative Name(s):
  • A transferase
  • A-transferase
  • Alpha-3-N-acetylgalactosaminyltransferase
  • Blood-group substance A-dependent acetylgalactosaminyltransferase
  • Blood-group substance alpha-acetyltransferase
  • Fucosylgalactose acetylgalactosaminyltransferase
  • Fucosylgalactose alpha-N-acetylgalactosaminyltransferase
  • Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
  • Histo-blood group A acetylgalactosaminyltransferase
  • Histo-blood group A glycosyltransferase (Fuc-alpha-1->2Gal-alpha-1->3-N-acetylgalactosaminyltransferase)
  • Histo-blood group A transferase
  • UDP-GalNAc:Fuc-alpha-1->2Gal-alpha-1->3-N-acetylgalactosaminyltransferase
  • UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase
  • UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase

EC 2.4.1.37: Fucosylgalactoside 3-alpha-galactosyltransferase

Reaction catalysed:
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R
Systematic name:
UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Alternative Name(s):
  • B transferase
  • Blood-group substance B-dependent galactosyltransferase
  • Blood-group substance alpha-dependent galactosyltransferase
  • Fucosylglycoprotein 3-alpha-galactosyltransferase
  • Glycoprotein-fucosylgalactoside alpha-galactosyltransferase
  • Histo-blood group B transferase
  • Histo-blood substance B-dependent galactosyltransferase
  • Histo-blood substance alpha-dependent galactosyltransferase
  • UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
  • UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase
  • UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase
  • UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
  • UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase
  • [Blood group substance] alpha-galactosyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF03414
Domain description: Glycosyltransferase family 6
Occurring in:
  1. Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
The deposited structure of PDB entry 5c4e contains 1 copy of Pfam domain PF03414 (Glycosyltransferase family 6) in Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005076
Domain description: Glycosyl transferase, family 6
Occurring in:
  1. Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form

Structure domain

CATH CATH domain
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
The deposited structure of PDB entry 5c4e contains 1 copy of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form. Showing 1 copy in chain A.

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