X-ray diffraction
1.43Å resolution

Crystal structure of Mcl-1 bound to BID-MM


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q07820 (Residues: 173-327; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
BH3-interacting domain death agonist p11 Chain: B
Molecule details ›
Chain: B
Length: 24 amino acids
Theoretical weight: 2.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P55957 (Residues: 80-101; Coverage: 11%)
Gene name: BID

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21212
Unit cell:
a: 80.83Å b: 37.02Å c: 56.92Å
α: 90° β: 90° γ: 90°
R R work R free
0.162 0.162 0.176
Expression systems:
  • Escherichia coli
  • Not provided