X-ray diffraction
1.9Å resolution

Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor DBT-GlcN


Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glucokinase 1, putative Chains: A, B
Molecule details ›
Chains: A, B
Length: 381 amino acids
Theoretical weight: 42.23 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q4E4E1 (Residues: 1-367; Coverage: 98%)
Gene name: Tc00.1047053510187.100
Sequence domains: Glucokinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 68.245Å b: 78.744Å c: 75.389Å
α: 90° β: 94.8° γ: 90°
R R work R free
0.199 0.197 0.237
Expression system: Escherichia coli BL21(DE3)