Structure analysis

Crystal structure of Trypanosoma cruzi glucokinase in complex with inhibitor CBZ-GlcN

X-ray diffraction
2.5Å resolution
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 28900 Å2
Buried surface area: 5700 Å2
Dissociation area: 2,400 Å2
Dissociation energy (ΔGdiss): 32 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -35 kcal/mol
Symmetry number: 2


Chains: A, B
Length: 381 amino acids
Theoretical weight: 42.23 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q4E4E1 (Residues: 1-367; Coverage: 98%)
Gene name: Tc00.1047053510187.100
Pfam: Glucokinase
InterPro: Glucokinase

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