› 5bqx

X-ray diffraction
2Å resolution

Crystal structure of human STING in complex with 3'2'-cGAMP

Released:
DOI: 10.2210/pdb5bqx/pdb
PDB entry 5bqx coloured by chain, front view.
PDB entry 5bqx coloured by chain, side view.
PDB entry 5bqx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Shi H, Wu J, Chen ZJ, Chen C
Proc Natl Acad Sci U S A 112 8947-52 (2015)
PMID: 26150511

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 138-379; Coverage: 64%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 4UR 1 x 4UR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41212
Unit cell:
a: 111.061Å b: 111.061Å c: 35.889Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.187 0.226
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.
Chen et al. (2016)
14 more

4 mentions without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)
3 more