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Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: chromatin organization
Cellular component: nucleus

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF04729
Domain description: ASF1 like histone chaperone
Occurring in:
  1. Histone chaperone ASF1B
The deposited structure of PDB entry 5bnx contains 1 copy of Pfam domain PF04729 (ASF1 like histone chaperone) in Histone chaperone ASF1B. Showing 1 copy in chain D.

PF12619
Domain description: Mini-chromosome maintenance protein 2
Occurring in:
  1. DNA replication licensing factor MCM2
The deposited structure of PDB entry 5bnx contains 1 copy of Pfam domain PF12619 (Mini-chromosome maintenance protein 2) in DNA replication licensing factor MCM2. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 5bnx contains 1 copy of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain B.

PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.3
The deposited structure of PDB entry 5bnx contains 1 copy of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.3
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.3
  2. Histone H4
IPR036747
Domain description: Histone chaperone ASF1-like superfamily
Occurring in:
  1. Histone chaperone ASF1B
IPR006818
Domain description: Histone chaperone ASF1-like
Occurring in:
  1. Histone chaperone ASF1B
IPR008045
Domain description: DNA replication licensing factor Mcm2
Occurring in:
  1. DNA replication licensing factor MCM2
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.3

Structure domains

CATH CATH domains
1.10.20.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Histone, subunit A
Homology: Histone, subunit A
Occurring in:
  1. Histone H3.3
  2. Histone H4
The deposited structure of PDB entry 5bnx contains 1 copy of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3.3. Showing 1 copy in chain A.
The deposited structure of PDB entry 5bnx contains 1 copy of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain B.
2.60.40.1490
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Histone chaperone ASF1-like
Occurring in:
  1. Histone chaperone ASF1B
The deposited structure of PDB entry 5bnx contains 1 copy of CATH domain 2.60.40.1490 (Immunoglobulin-like) in Histone chaperone ASF1B. Showing 1 copy in chain D.

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