› 5bna

X-ray diffraction
2.6Å resolution

THE PRIMARY MODE OF BINDING OF CISPLATIN TO A B-DNA DODECAMER: C-G-C-G-A-A-T-T-C-G-C-G

Released:
DOI: 10.2210/pdb5bna/pdb
PDB entry 5bna coloured by chain, front view.
PDB entry 5bna coloured by chain, side view.
PDB entry 5bna coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G.
Wing RM, Pjura P, Drew HR, Dickerson RE
EMBO J 3 1201-6 (1984)
PMID: 6539674

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118429 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand PTN 3 x PTN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 24.16Å b: 39.93Å c: 66.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.102 not available not available
Expression system: Not provided

Quick links

Citations

4 review citations

The effect of the base sequence on the fine structure of the DNA double helix.
Shakked et al. (1986)
3 more

7 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
6 more