› 5bkk

Electron Microscopy
3.5Å resolution

bbTBA-bound closed MthK channel in nanodisc

Released:
DOI: 10.2210/pdb5bkk/pdb
PDB entry 5bkk coloured by chain, front view.
PDB entry 5bkk coloured by chain, side view.
PDB entry 5bkk coloured by chain, top view.
Source organism: Methanothermobacter thermautotrophicus
Primary publication:
Calcium-gated potassium channel blockade via membrane-facing fenestrations.
Fan C, Flood E, Sukomon N, Agarwal S, Allen TW, Nimigean CM
Nat Chem Biol (2023)
PMID: 37653172
Related structures: EMD-9407

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-gated potassium channel MthK Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 336 amino acids
Theoretical weight: 37.36 KDa
Source organism: Methanothermobacter thermautotrophicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O27564 (Residues: 1-336; Coverage: 100%)
Gene names: MTH_1520, mthK
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand PGW 2 x PGW
Ligand K 3 x K
Ligand YQ4 1 x YQ4
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-9407
Expression system: Escherichia coli

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