5b6m

X-ray diffraction
2.5Å resolution

Crystal structure of human peroxiredoxin 6 in reduced state

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structures of human peroxiredoxin 6 in different oxidation states.
Biochem. Biophys. Res. Commun. (2016)
PMID: 27353378

Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 224 amino acids
Theoretical weight: 25.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: P30041 (Residues: 1-224; Coverage: 100%)
Gene names: AOP2, KIAA0106, PRDX6
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 94.353Å b: 106.349Å c: 165.504Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.233 0.29
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4