5b4x

X-ray diffraction
3.2Å resolution

Crystal structure of the ApoER2 ectodomain in complex with the Reelin R56 fragment

Released:
Source organisms:
Entry authors: Yasui N, Hirai H, Yamashita K, Takagi J, Nogi T

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Reelin Chains: A, C
Molecule details ›
Chains: A, C
Length: 725 amino acids
Theoretical weight: 81.79 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q60841 (Residues: 1948-2662; Coverage: 21%)
Gene names: Reln, Rl
Structure domains: Galactose-binding domain-like
Low-density lipoprotein receptor-related protein 8 Chains: B, D
Molecule details ›
Chains: B, D
Length: 570 amino acids
Theoretical weight: 63.65 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q14114 (Residues: 42-736; Coverage: 61%)
  • Best match: Q14114-2 (Residues: 42-607)
Gene names: APOER2, LRP8
Sequence domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P65
Unit cell:
a: 205.951Å b: 205.951Å c: 169.84Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.2 0.255
Expression system: Cricetulus griseus