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Crystal structure of D-3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis complexed with NAD+ and a substrate D-3-hydroxybutyrate

Source organism: Alcaligenes faecalis
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

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EC 1.1.1.30: 3-hydroxybutyrate dehydrogenase

Reaction catalysed:
(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH
Systematic name:
(R)-3-hydroxybutanoate:NAD(+) oxidoreductase
Alternative Name(s):
  • 3-D-hydroxybutyrate dehydrogenase
  • Beta-hydroxybutyrate dehydrogenase
  • Beta-hydroxybutyric acid dehydrogenase
  • Beta-hydroxybutyric dehydrogenase
  • D-(-)-3-hydroxybutyrate dehydrogenase
  • D-3-hydroxybutyrate dehydrogenase
  • D-beta-hydroxybutyrate dehydrogenase
  • Hydroxybutyrate oxidoreductase
  • NAD-beta-hydroxybutyrate dehydrogenase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00106
Domain description: short chain dehydrogenase
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase
The deposited structure of PDB entry 5b4t contains 1 copy of Pfam domain PF00106 (short chain dehydrogenase) in 3-hydroxybutyrate dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase
IPR011294
Domain description: 3-hydroxybutyrate dehydrogenase
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. D-3-hydroxybutyrate dehydrogenase
The deposited structure of PDB entry 5b4t contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in 3-hydroxybutyrate dehydrogenase. Showing 1 copy in chain A.

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