Structure analysis

X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8.

X-ray diffraction
3.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 38900 Å2
Buried surface area: 3000 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 9 kcal/mol
Interface energy (ΔGint): -61 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 986 amino acids
Theoretical weight: 108.69 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NRR4 (Residues: 411-1365; Coverage: 70%)
Gene names: DROSHA, RN3, RNASE3L, RNASEN
Pfam:
InterPro:

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Chains: B, C
Length: 39 amino acids
Theoretical weight: 4.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WYQ5 (Residues: 728-750; Coverage: 3%)
Gene names: C22orf12, DGCR8, DGCRK6, LP4941

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