5axc

X-ray diffraction
1.55Å resolution

Crystal structure of mouse SAHH complexed with 3'-keto aristeromycin

Released:
Source organism: Mus musculus
Entry authors: Kusakabe Y, Ishihara M, Tanaka N

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosylhomocysteinase Chains: A, C
Molecule details ›
Chains: A, C
Length: 432 amino acids
Theoretical weight: 47.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P50247 (Residues: 1-432; Coverage: 100%)
Gene name: Ahcy
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Spacegroup: I222
Unit cell:
a: 98.202Å b: 102.881Å c: 174.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.21
Expression system: Escherichia coli