PDBe 5alw

X-ray diffraction
2.2Å resolution

ligand complex structure of soluble epoxide hydrolase

Released:
Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
An epoxide + H(2)O = a glycol
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional epoxide hydrolase 2 Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34913 (Residues: 1-548; Coverage: 99%)
Gene name: EPHX2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+
Spacegroup: P6522
Unit cell:
a: 92.546Å b: 92.546Å c: 245.135Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.246
Expression system: Spodoptera frugiperda