5ac2

X-ray diffraction
1.85Å resolution

human aldehyde dehydrogenase 1A1 with duocarmycin analog

Released:

Function and Biology Details

Reaction catalysed:
Retinal + NAD(+) + H(2)O = retinoate + NADH
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinal dehydrogenase 1 Chain: A
Molecule details ›
Chain: A
Length: 501 amino acids
Theoretical weight: 54.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00352 (Residues: 1-501; Coverage: 100%)
Gene names: ALDC, ALDH1, ALDH1A1, PUMB1
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand TXE 1 x TXE
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P422
Unit cell:
a: 109.123Å b: 109.123Å c: 83.175Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.251
Expression system: Escherichia coli