Function and Biology

S.enterica HisA mutant D7N, G102A, V106M, D176A

EC 5.3.1.16: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase

Reaction catalysed:
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
Systematic name:
1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide aldose-ketose-isomerase
Alternative Name(s):
  • 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide ketol-isomerase
  • N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase
  • N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase
  • Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
  • Phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase

Sequence family

Pfam Protein family (Pfam)
PF00977
Domain description: Histidine biosynthesis protein
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
1 copy of Pfam domain PF00977 (Histidine biosynthesis protein) in 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase in PDB 5abt.

InterPro InterPro annotations
IPR006063
Domain description: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
IPR023016
Domain description: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA-like
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
IPR013785
IPR006062
Domain description: Histidine biosynthesis protein
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
1 copy of CATH domain 3.20.20.70 (TIM Barrel) in 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase in PDB 5abt.