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Structure of GH84 with ligand

Source organism: Bacteroides thetaiotaomicron
Biochemical function: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological process: carbohydrate derivative metabolic process
Cellular component: not assigned

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EC 3.2.1.169: Protein O-GlcNAcase

Reaction catalysed:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine
Systematic name:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase
Alternative Name(s):
  • BtGH84
  • Glycoside hydrolase O-GlcNAcase
  • O-GlcNAc hydrolase
  • O-GlcNAcase
  • OGA

GO terms

Sequence families

Pfam Protein families (Pfam)
PF18344
Domain description: Carbohydrate binding module family 32
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of Pfam domain PF18344 (Carbohydrate binding module family 32) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.

PF21809
Domain description: Bacterial GH84, post-catalytic domain
Occurring in:
  1. O-GlcNAcase BT_4395

PF07555
Domain description: beta-N-acetylglucosaminidase
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of Pfam domain PF07555 (beta-N-acetylglucosaminidase) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.

PF02838
Domain description: Glycosyl hydrolase family 20, domain 2
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of Pfam domain PF02838 (Glycosyl hydrolase family 20, domain 2) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029018
Domain description: Beta-hexosaminidase-like, domain 2
Occurring in:
  1. O-GlcNAcase BT_4395
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. O-GlcNAcase BT_4395
IPR011496
Domain description: Beta-N-acetylglucosaminidase, catalytic domain
Occurring in:
  1. O-GlcNAcase BT_4395
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. O-GlcNAcase BT_4395
IPR015882
Domain description: Beta-hexosaminidase, bacterial type, N-terminal
Occurring in:
  1. O-GlcNAcase BT_4395
IPR048162
Domain description: O-GlcNAcase BT_4395-like
Occurring in:
  1. O-GlcNAcase BT_4395

Structure domains

CATH CATH domains
1.20.58.460
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: Hyaluronidase post-catalytic domain-like
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of CATH domain 1.20.58.460 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of CATH domain 3.20.20.80 (TIM Barrel) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.
3.30.379.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chitobiase; domain 2
Homology: Chitobiase/beta-hexosaminidase domain 2-like
Occurring in:
  1. O-GlcNAcase BT_4395
The deposited structure of PDB entry 5abh contains 2 copies of CATH domain 3.30.379.10 (Chitobiase; domain 2) in O-GlcNAcase BT_4395. Showing 1 copy in chain A.

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