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Native mammalian ribosome-bound Sec61 protein-conducting channel in the 'non-inserting' state

Electron Microscopy
9Å resolution
PDB entry 5a6u coloured by chain, front view.
PDB entry 5a6u coloured by chain, side view.
PDB entry 5a6u coloured by chain, top view.
Source organism: Canis lupus familiaris
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein transport protein Sec61
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Multimeric state: hetero trimer
Accessible surface area: 28904.47 Å2
Buried surface area: 4859.9 Å2
Dissociation area: 990.1 Å2
Dissociation energy (ΔGdiss): 11.9 kcal/mol
Dissociation entropy (TΔSdiss): 10.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153620

Macromolecules

Protein transport protein Sec61 subunit alpha isoform 1
Chain: A
Length: 451 amino acids
Theoretical weight: 49.32 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P38377 (Residues: 26-476; Coverage: 95%)
Gene name: SEC61A1
Pfam:
InterPro:
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 5a6u, assembly 1, front view.
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 5a6u, assembly 1, side view.
Protein transport protein Sec61 subunit alpha isoform 1 in PDB entry 5a6u, assembly 1, top view.
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Protein transport protein Sec61 subunit beta
Chain: B
Length: 36 amino acids
Theoretical weight: 3.99 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P60467 (Residues: 61-96; Coverage: 38%)
Gene name: SEC61B
Pfam: Sec61beta family
InterPro:
Protein transport protein Sec61 subunit beta in PDB entry 5a6u, assembly 1, front view.
Protein transport protein Sec61 subunit beta in PDB entry 5a6u, assembly 1, side view.
Protein transport protein Sec61 subunit beta in PDB entry 5a6u, assembly 1, top view.
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Protein transport protein Sec61 subunit gamma
Chain: G
Length: 62 amino acids
Theoretical weight: 7.02 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P60058 (Residues: 7-68; Coverage: 91%)
Gene name: SEC61G
Pfam: SecE/Sec61-gamma subunits of protein translocation complex
InterPro:
Protein transport protein Sec61 subunit gamma in PDB entry 5a6u, assembly 1, front view.
Protein transport protein Sec61 subunit gamma in PDB entry 5a6u, assembly 1, side view.
Protein transport protein Sec61 subunit gamma in PDB entry 5a6u, assembly 1, top view.
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