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Structure of mammalian eIF3 in the context of the 43S preinitiation complex

Electron Microscopy
6Å resolution
PDB entry 5a5t coloured by chain, front view.
PDB entry 5a5t coloured by chain, side view.
PDB entry 5a5t coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Assembly composition:
hetero octamer (preferred)
Entry contents: 8 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero octamer
Accessible surface area: 154881.75 Å2
Buried surface area: 41707.29 Å2
Dissociation area: 2,237.91 Å2
Dissociation energy (ΔGdiss): 19.17 kcal/mol
Dissociation entropy (TΔSdiss): 16.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-124208

Macromolecules

Eukaryotic translation initiation factor 3 subunit A
Chain: A
Length: 1362 amino acids
Theoretical weight: 164.9 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SMZ5 (Residues: 1-1362; Coverage: 100%)
Gene names: EIF3A, EIF3S10
Pfam: PCI domain
InterPro:
Eukaryotic translation initiation factor 3 subunit A in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit A in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit A in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit C
Chain: C
Length: 843 amino acids
Theoretical weight: 97.92 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1U971 (Residues: 71-913; Coverage: 92%)
Gene names: EIF3C, EIF3S8
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit C in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit C in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit C in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit E
Chain: E
Length: 445 amino acids
Theoretical weight: 52.28 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SUC8 (Residues: 18-462; Coverage: 96%)
Gene names: EIF3E, EIF3S6, INT6
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit E in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit E in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit E in PDB entry 5a5t, assembly 1, top view.
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EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F
Chain: F
Length: 364 amino acids
Theoretical weight: 37.85 KDa
Source organism: Oryctolagus cuniculus
InterPro:
EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F in PDB entry 5a5t, assembly 1, front view.
EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F in PDB entry 5a5t, assembly 1, side view.
EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit H
Chain: H
Length: 352 amino acids
Theoretical weight: 39.95 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1ST95 (Residues: 12-363; Coverage: 97%)
Gene names: EIF3H, EIF3S3
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit H in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit H in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit H in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit K
Chain: K
Length: 218 amino acids
Theoretical weight: 25.13 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1T3L2 (Residues: 1-218; Coverage: 100%)
Gene names: EIF3K, EIF3S12
Pfam: CSN8/PSMD8/EIF3K family
InterPro:
Eukaryotic translation initiation factor 3 subunit K in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit K in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit K in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit L
Chain: L
Length: 564 amino acids
Theoretical weight: 66.8 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SED9 (Residues: 44-607; Coverage: 93%)
Gene names: EIF3EIP, EIF3L, EIF3S6IP
Pfam: RNA polymerase I-associated factor PAF67
InterPro:
Eukaryotic translation initiation factor 3 subunit L in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit L in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit L in PDB entry 5a5t, assembly 1, top view.
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Eukaryotic translation initiation factor 3 subunit M
Chain: M
Length: 374 amino acids
Theoretical weight: 42.56 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: G1SLW8 (Residues: 1-374; Coverage: 100%)
Gene name: EIF3M
Pfam:
InterPro:
Eukaryotic translation initiation factor 3 subunit M in PDB entry 5a5t, assembly 1, front view.
Eukaryotic translation initiation factor 3 subunit M in PDB entry 5a5t, assembly 1, side view.
Eukaryotic translation initiation factor 3 subunit M in PDB entry 5a5t, assembly 1, top view.
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