Structure analysis

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core

Electron Microscopy
3.5Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero 28-mer (preferred)
Entry contents: 14 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 28-mer
Accessible surface area: 202461.85 Å2
Buried surface area: 86759.04 Å2
Dissociation area: 6,149.99 Å2
Dissociation energy (ΔGdiss): 47.83 kcal/mol
Dissociation entropy (TΔSdiss): 28.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127173

Macromolecules

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Chains: J, X
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49720 (Residues: 2-205; Coverage: 100%)
Gene name: PSMB3
Pfam: Proteasome subunit
InterPro:
CATH: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

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Chains: K, Y
Length: 201 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49721 (Residues: 1-201; Coverage: 100%)
Gene name: PSMB2
Pfam: Proteasome subunit
InterPro:
CATH: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

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Chains: M, a
Length: 213 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P20618 (Residues: 29-241; Coverage: 88%)
Gene names: PSC5, PSMB1
Pfam: Proteasome subunit
InterPro:
CATH: Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1

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