X-ray diffraction
3.3Å resolution

Crystal Structure of the Human Coronavirus SARS HR1 motif in complex with pan-CoVs inhibitor EK1


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike protein S2' Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 80 amino acids
Theoretical weight: 8.7 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli
  • Canonical: P59594 (Residues: 892-970; Coverage: 6%)
Gene names: 2, S
pan-CoV inhibitory peptide EK1 Chains: a, b, c
Molecule details ›
Chains: a, b, c
Length: 44 amino acids
Theoretical weight: 4.92 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P43212
Unit cell:
a: 100.958Å b: 100.958Å c: 73.425Å
α: 90° β: 90° γ: 90°
R R work R free
0.251 0.248 0.301
Expression system: Escherichia coli