PDBe 5zo7

X-ray diffraction
2.6Å resolution

Kinesin spindle protein Eg5 in complex with STLC-type inhibitor PVEI0138

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 367 amino acids
Theoretical weight: 41.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 17-369; Coverage: 33%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: C2
Unit cell:
a: 158.347Å b: 50.58Å c: 93.689Å
α: 90° β: 102.2° γ: 90°
R-values:
R R work R free
0.231 0.225 0.283
Expression system: Escherichia coli BL21(DE3)