PDBe 5yvh

X-ray diffraction
3.15Å resolution

Crystal structure of Karyopherin beta2 in complex with FUS(371-526)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 868 amino acids
Theoretical weight: 98.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92973 (Residues: 9-344, 376-898; Coverage: 96%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
RNA-binding protein FUS Chain: B
Molecule details ›
Chain: B
Length: 158 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35637 (Residues: 371-526; Coverage: 30%)
Gene names: FUS, TLS
Sequence domains: Zn-finger in Ran binding protein and others

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 129.425Å b: 156.532Å c: 67.822Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.262
Expression system: Escherichia coli BL21(DE3)